BCH 5045     GRADUATE SURVEY OF BIOCHEMISTRY     OnLine, FALL 2009
Animated Gifs above are from The RCSB PDB WWW address: http://www.rcsb.org/pdb/. The original journal reference for the BNL PDB is: F.C.Bernstein, T.F.Koetzle, G.J.Williams, E.E.Meyer Jr, M.D.Brice, J.R.Rodgers, O.Kennard, Shimanouchi, M.Tasumi. The Protein Data Bank: a computer-based archival file for macromolecular structures. J. Mol. Biol. 112 pp. 535 (1977). Can you guess what the rotating structures are? See bottom of page for the answer.

 


 
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1100 BIOCHEMICAL TERMS USED IN BCH 5045
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Dr. Charles Guy
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Answer for above.

Ribosomes are composed of two subunits: a large subunit, shown on the left, and a small subunit, shown on the right. The term "small" is relative as both the large and the small subunits are huge compared to say the average protein. Both subunits are composed of long strands of RNA, shown here in orange and yellow. Protein chains are shown in blue. When making a new protein, the two subunits lock together with the messenger RNA threaded through them. The ribosome then advances down the messenger RNA three nucleotides at a time, building a new protein one amino acid after another.

updated 9/22/09.